It is peeve amazing how many hours get burnt while trying to resolve simple package dependency issues. I may be too dumb to proffer a lasting one-fits-all solution to all dependency issues, but I got this issue fixed in my own case. Problem Description: The python-axolotl library requires certain dependencies that are not properly managed when installing libraries via a command line's requirement.txt file. I got real help by reading through this link below, but this page might be more helpful when it comes to detailed instructions. Actual instructions: https://github.com/tgalal/python-axolotl Typical errors might look like the following: 1. In this case, missing library(s). Libraries needed for compiling some python resources. Unfortunately, http://aka.ms/vcpython27 has been decommissioned because Python2x is EOL. You can still get the VcPython27 from an archive at https://web.archive.org/web/20210106040222/download.microsoft.com/download/7/9/6/796EF2E4-801B-4FC4-AB28-B5